Metabolic ‘reprogramming’ by the p53 gene family leads to tumor regression

Lyra Nara Blog

Scientists have found that altering members of the p53 gene family, known as tumor suppressor genes, causes rapid regression of tumors that are deficient in or totally missing p53. Study results suggest existing diabetes drugs, which impact the same gene-protein pathway, might be effective for cancer treatment.

The University of Texas MD Anderson Cancer Center investigation showed that, in vivo, the genes p63 and p73 can be manipulated to upregulate or increase levels of IAPP, a protein important for the body’s ability to metabolize glucose. IAPP is found in somediabetes drugs already on the market.

The research findings were published in today’s issue of Nature.

The study, led by Elsa R. Flores, Ph.D., associate professor of molecular and cellular oncology, centered on p63 and p73 because of the genes’ ability to cause tumor regression or spur its growth due to their unique genetic makeup.

“P53 is altered in…

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