Low testosterone and prostate cancer

Men who are fat ~high estrogen and low testosterone are at higher risk for prostate cancer #pubmed http://ubmed.com/m/31621000

One thought on “Low testosterone and prostate cancer

  1.   
    One wonders about this kind of research. Most of the prostate cancer patients I see are elderly when the prevalence of biochemical testosterone deficiency increases with age. This is partly due to decreasing testosterone levels associated with illness or debility but there is also convincing epidemiological data to show that serum free and total testosterone levels also fall with normal aging .However I do see quite a few younger men in late 40s and early 50s who have testosterone levels one would expect at such and age.
    What is probably more behind the problem is genetics. Examples of genes where polymorphisms may exist could these be behind the cancers.
    BRCA2   NKX3A  NKX3. PTEN  RB1   PCA3   KAI1  HPC1  ELAC2   MSR1  RNASEL  SIRT1  ANP32C  ANP32D  BTG1  DLEC1  FOXP1  GAK ANP32C  ANP32D  BTG1  HDAC3  GAS11  LAPSER1  NAP114  TIM1  THW  TP63  TSSC3 TP13  MYC  RAS  BCL-2  TP13
    Alastair

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