Men who are fat ~high estrogen and low testosterone are at higher risk for prostate cancer #pubmed http://ubmed.com/m/31621000
Low testosterone and prostate cancer
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One wonders about this kind of research. Most of the prostate cancer patients I see are elderly when the prevalence of biochemical testosterone deficiency increases with age. This is partly due to decreasing testosterone levels associated with illness or debility but there is also convincing epidemiological data to show that serum free and total testosterone levels also fall with normal aging .However I do see quite a few younger men in late 40s and early 50s who have testosterone levels one would expect at such and age.
What is probably more behind the problem is genetics. Examples of genes where polymorphisms may exist could these be behind the cancers.
BRCA2 NKX3A NKX3. PTEN RB1 PCA3 KAI1 HPC1 ELAC2 MSR1 RNASEL SIRT1 ANP32C ANP32D BTG1 DLEC1 FOXP1 GAK ANP32C ANP32D BTG1 HDAC3 GAS11 LAPSER1 NAP114 TIM1 THW TP63 TSSC3 TP13 MYC RAS BCL-2 TP13
Alastair