Berberine inhibits PDL1 expression

BERBERINE INHIBITS PDL1 expression in mice tumors. Questions : does this help or decrease PDL1 inhibitors effectivity

One thought on “Berberine inhibits PDL1 expression

  1. More on Berberine which has a wide range of use in alternative medicine as well as geral and specialsed medicine
    Not only is it good in cancer therapy esp melanoma and as part of many Black salve formulations.
    When taken by mouth: Berberine is pretty safe for most adults for short-term use when taken by mouth. Side effects may include diarrhea, constipation, gas, stomach upset, and headache. When applied to the skin: Berberine is normally safe  for most adults when used short-term.
    Berberine is one of the most effective natural supplements available for so many conditions example go here https://www.hindawi.com/journals/omcl/2015/723093/?utm_s.
    It has very impressive health benefits, and affects your body at the molecular level.
    Berberine has been shown to lower blood sugar, cause weight loss and improve heart health, to name a few.
    It is one of the few supplements shown to be as effective as a pharmaceutical drug.
    Berberine is a bioactive compound that can be extracted from several different plants, including a group of shrubs called Berberis.
    Technically, it belongs to a class of compounds called alkaloids It has a yellow color, and has often been used as a dye.
    Berberine has a long history of use in traditional Chinese medicine, where it was used to treat various ailments.
    Modern science has confirmed that it has impressive benefits for several different health problems .
    Examples  twenty-seven randomized controlled clinical trials were included with 2569 patients. There are seven subgroups in the meta-analysis: berberine versus placebo or berberine with intensive lifestyle intervention versus intensive lifestyle intervention alone; berberine combined with oral hypoglycemic versus hypoglycemic alone; berberine versus oral hypoglycemic; berberine combined with oral lipid lowering drugs versus lipid lowering drugs alone; berberine versus oral lipid lowering drugs; berberine combined with oral hypotensor versus hypotensive medications; berberine versus oral hypotensive medications. In the treatment of type 2 diabetes mellitus, we found that berberine with lifestyle intervention tended to lower the level of FPG, PPG and HbA1c than lifestyle intervention alone or placebo; the same as berberine combined with oral hypoglycemics to the same hypoglycemics; but there was no statistical significance between berberine and oral hypoglycemics. As for the treatment of hyperlipidemia, berberine with lifestyle intervention was better than lifestyle intervention, berberine with oral lipid lowering drugs was better than lipid lowering drugs alone in reducing the level of TC and LDL-C, and raising the level of HDL-C. In the comparative study between berberine and oral lipid lowering drugs, there was no statistical significance in reducing the level of TC and LDL-C, but berberine shows better effect in lowering the level of TG and raising the level of HDL-C. In the treatment of hypertension, berberine with lifestyle intervention tended to lower the level of blood pressure more than the lifestyle intervention alone or placebo did; The same occurred when berberine combined with oral hypotensor was compared to the same hypotensor. Notably, no serious adverse reaction was reported in the 27 experiments.  
    Berberine has now been tested in hundreds of different studies.
    It has been shown to have powerful effects on many different biological systems .
    After you ingest berberine, it gets taken in by the body and transported into the bloodstream. Then it travels into the body’s cells.
    Inside the cells, it binds to several different “molecular targets” and changes their function . This is similar to how pharmaceutical drugs work.
      I am not going to get into much detail here, because the biological mechanisms are complicated and diverse.
    However, one of the main actions of berberine is to activate an enzyme inside cells called  AMP -ACTIVATED PROTEIN KINASE (AMPK) .
    This enzyme is sometimes referred to as a “metabolic master switch” .
    It is found in the cells of various organs, including the brain, muscle, kidney, heart and liver. This enzyme plays a major role in regulating metabolism .
    Berberine also affects various other molecules inside cells, and may even affect which genes are turned on or off
    Berberine affects the body at the molecular level, and has a variety of functions inside cells. One of the main functions is activating an important enzyme called AMPK, which regulates metabolism.
    All very good reasons to research and use .
    Alastair

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